From NGS assembly challenges to instability of fungal mitochondrial genomes: A case study in genome complexity
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- 作者：Elizabeth Misasa ; b ; José ; Fernando Muñ ; oza ; b ; Juan Esteban Galloa ; c ; Juan Guillermo McEwena ; d ; Oliver Keatinge Claya ; e ; oliver.clay@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：NGS ; next generation sequencing ; mt ; mitochondrial ; mtDNA ; mitochondrial DNA ; nt ; nucleotide ; bp ; base pair ; kb ; kilobase pair ; Mb ; megabase pair ; ori ; origin of replication ; orf ; open reading frame
- 刊名：Computational Biology and Chemistry
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：61
- 期：Complete
- 页码：258-269
- 全文大小：719 K
文摘
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Fungal mitochondrial genomes can have complex repeat systems.
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Repeats in mitochondrial genomes can mislead short-read assembly programs.
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Repeats can also lead to illegitimate intrachromosomal recombination and large-scale deletions.
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Where persistent repeats are stably present, their locations can indicate functional or structural importance.