Kefiran-alginate gel microspheres for oral delivery of ciprofloxacin
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- 作者：Lina M. Blandó ; na ; German A. Islanb ; Guillermo R. Castrob ; Miguel D. Nosedac ; Vanete Thomaz-Soccola ; Carlos R. Soccola ; soccol@ufpr.br" class="auth_mail" title="E-mail the corresponding author ; carlosricardo.soccol@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hybrid gel microspheres ; Kefiran ; Alginate ; Ciprofloxacin ; Antimicrobial activity ; Controlled release ; Kefiran-ciprofloxacin complex
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：145
- 期：Complete
- 页码：706-715
- 全文大小：1940 K
文摘
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Hybrid gel microspheres composed by alginate and kefiran were developed.
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Kefiran-alginate microspheres protect the antibiotic from acid gastric conditions.
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FTIR and thermogravimetry suggest non-covalent interactions between the matrix components.
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Kefiran microspheres showed controlled release of ciprofloxacin.
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Kefiran and ciprofloxacin showed complementary antimicrobial activities.