Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity

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• 作者：Malgorzata Debiak ; Kai Kehe ; Alex ; er Bü ; rkle
• 关键词：Sulfur mustard ; PARP ; DNA repair ; Cell death ; NAD⁺ ; 3-Aminobenzamide
• 刊名：Toxicology
• 出版年：2009
• 出版时间：1 September 2009
• 年：2009
• 卷：263
• 期：1
• 页码：20-25
• 全文大小：187 K

文摘

Sulfur mustard (SM) is a chemical warfare agent leading to severe blistering of skin and mucosal surfaces, and as a long-term effect, to an increased risk for malignancies. At the molecular level, SM acts as a bifunctional alkylating agent, leading to DNA mono-adducts and di-adducts. This review is focussed on the role of poly(ADP-ribosyl)ation in the cell and tissue responses to SM-induced damage and potential role of inhibitors of poly(ADP-ribosyl)ation as therapeutic agents for SM injury.