- 作者：Hisanori Ariga ; Kenji Nemoto ; Shukichi Miyazaki ; Takashi Yoshioka ; Yohishiro Ogawa ; Toru Sakayauchi ; Keiichi Jingu ; Go Miyata ; Ko Onodera ; Hirofumi Ichikawa ; Takashi Kamei ; Shunsuke Kato ; Chikashi Ish
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2009
- 出版时间：1 October 2009
- 年：2009
- 卷：75
- 期：2
- 页码：348-356
- 全文大小：255 K
Purpose
Esophagectomy remains the mainstay treatment for esophageal cancer, although retrospective studies have suggested that chemoradiotherapy (CRT) is as effective as surgery. To determine whether CRT can substitute for surgery as the primary treatment modality, we performed a prospective direct comparison of outcomes after treatment in patients with resectable esophageal cancer who had received CRT and those who had undergone surgery.Methods and Materials
Eligible patients had resectable T1–3N0–1M0 thoracic esophageal cancer. After the surgeon explained the treatments in detail, the patients selected either CRT (CRT group) or surgery (OP group). The CRT course consisted of two cycles of cisplatin and fluorouracil with split-course concurrent radiotherapy of 60Gy in 30 fractions. Patients with progressive disease during CRT and/or with persistent or recurrent disease after CRT underwent salvage resection.
Results
Of 99 eligible patients with squamous cell carcinoma registered between January 2001 and December 2005, 51 selected CRT and 48 selected surgery. Of the patients in the CRT group, 13 (25.5 % ) underwent esophagectomy as salvage therapy. The 3- and 5-year survival rates were 78.3 % and 75.7 % , respectively, in the CRT group compared with 56.9 % and 50.9 % , respectively, in the OP group (p = 0.0169). Patients in the OP group had significantly more metastatic recurrence than those in the CRT group.
Conclusions
Treatment outcomes among patients with resectable thoracic esophageal squamous cell carcinoma were comparable or superior after CRT (with salvage therapy if needed) to outcomes after surgery alone.