Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia
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- 作者：Ohta ; Kentaro ; Iwai ; Masanori ; Sato ; Keiko ; Omori ; Nobuhiko ; Nagano ; Isao ; Shoji ; Mikio ; Abe ; Koji
- 关键词：Brain infarction ; Transient ischemia ; Aging ; Remyelination ; Oligodendrocyte progenitor cell ; Neuron-glial antigen 2 (NG2) ; ANOVA ; analysis of variance ; CBF ; cerebral blood flow ; CNS ; central nervous system ; MCA ; middle cerebral artery ; MCAO ; middle cerebr
- 刊名：Neuroscience Letters
- 出版年：2003
- 出版时间：January 2, 2003
- 年：2003
- 卷：335
- 期：3
- 页码：159-162
- 全文大小：177 K
文摘
To investigate the effect of aging on the oligodendrocyte progenitor cells (OPCs) after cerebral ischemia, neuron-glia antigen 2 (NG2) chondroitin sulfate proteoglycan was examined at 1, 3 and 7 days after 90 min of transient middle cerebral artery occlusion in young and aged brains. The number of NG2 positive cells increased in the ischemic penumbra at 3 and 7 days after reperfusion, while those decreased in the ischemic core. At 7 days, the number of NG2 positive cells was significantly greater in the young than the aged brains, and the processes of NG2 positive cells enlarged and were highly branched in the young than the aged brains. These results suggest that the young brain showed a higher potential of proliferation and process branching of OPCs than the aged brains.