Fructose suppresses uric acid excretion to the intestinal lumen as a result of the induction of oxidative stress by NADPH oxidase activation

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• 作者：Chihiro Kaneko^a ; Jiro Ogura^a ; Shunichi Sasaki^a ; Keisuke Okamoto^a ; Masaki Kobayashi^b ; ^{masaki@pharm.hokudai.ac.jp} ; Kaori Kuwayama^a ; Katsuya Narumi^a ; Ken Iseki^a ; ^b ; ^{ken-i@pharm.hokudai.ac.jp}
• 关键词：Hyperuricemia ; Fructose ; Uric acid excretion ; Breast cancer resistance protein ; Oxidative stress ; NADPH oxidase
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1861
• 期：3
• 页码：559-566
• 全文大小：706 K
• 卷排序：1861

文摘

The single administration of fructose suppresses the function of uric acid excretion in the ileum. The single administration of fructose decreases in BCRP homodimer level. The activation of Nox is associated with the effects of fructose on uric acid excretion.