Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women
详细信息 查看全文
- 作者：Satoyo Hosonoa ; shosono@aichi-cc.jp" class="auth_mail" title="E-mail the corresponding author ; Hidemi Itoa ; Isao Ozea ; Yasuki Higakib ; Emi Moritac ; d ; Naoyuki Takashimae ; Sadao Suzukif ; Keiichi Shimatanig ; Haruo Mikamih ; Keizo Ohnakai ; Etsuko Ozakij ; Sakurako Katsuura-Kamanok ; Michiaki Kubol ; Chisato Nagatam ; Mariko Naitoc ; Nobuyuki Hamajiman ; Hideo Tanakaa ; for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group
- 关键词：Cross-sectional study ; Polymorphisms in CYP19A1 ; HSD17B1 and HSD17B2 ; Sex hormone concentration
- 刊名：Maturitas
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：82
- 期：4
- 页码：394-401
- 全文大小：549 K
文摘
- •
Several CYP19A1 and HSD17B2 genotypes affect serum estrone and estradiol level.
- •
The effect of these polymorphisms is independent of current BMI.
- •
They might be associated with the etiology of estrogen-dependent cancer.
- •
The strength of this study is its large sample size.
- •
Our results may be widely generalizable for postmenopausal Japanese women.