The angiographic and clinical outcomes after coronary stenting in patients with metabolic syndrome

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• 作者：Di Xu^a ; ¹ ; Yan Guo^a ; Hui Wang^a ; ^d ; ¹ ; Bing Gu^b ; Genyan Liu^b ; Chuanwei Zhou^a ; Xin Wu^c ; Junhong Wang^a ; ^{cnjjh2000@yahoo.com.cn} ; Kejiang Cao^a
• 关键词：Metabolic syndrome ; Coronary artery disease ; Stents
• 刊名：Atherosclerosis
• 出版年：2012
• 出版时间：April, 2012
• 年：2012
• 卷：221
• 期：2
• 页码：416-421
• 全文大小：539 K

文摘

Background

Metabolic syndrome (MetS) is regarded as a risk factor for coronary artery disease (CAD). But the influence of MetS on morbidity and mortality after stent implantation in CAD patients remains unknown.

Methods

This article presents a meta-analysis of available data on the association between the MetS and the risk of angiographic and clinical outcomes following stent implantation.

Results

MetS was associated with a significant increased risk of post-stent all-cause mortality (odd ratio (OR), 2.17, 95 % CI, 1.56-3.01), in-lesion restenosis (OR, 1.35, 95 % CI, 1.00-1.84) and major adverse cardiac events (MACE) (OR 1.35, 95 % CI 1.13-1.61) in CAD patients. Even with drug-eluting stent (DES) implantation, significant increased risk in all-cause mortality (OR, 2.25, 95 % CI, 1.61-3.15) and MACE (OR 1.42, 95 % CI 1.14-1.76) were remain in patients with MetS. However, the OR of cardiovascular (CV) mortality (1.25, 95 % CI 0.71-2.22), MI (1.27, 95 % CI 0.87-1.85) and TLR (OR 1.21, 95 % CI 0.96-1.53) was not statistically different between the patients with and without metabolic syndrome.

Conclusions

Metabolic syndrome is an important risk factor in patients with CAD following stent implantation. Although DES implantation decreased the incidence of angiographic events, further progress in adequate treatment of MetS is still required to improve the clinical outcome.