Diverse effects of naturally occurring base lesions on the structure and stability of the human telomere DNA quadruplex
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- 作者：Helena Konvalinová ; a ; b ; c ; Zuzana Dvořá ; ková ; a ; b ; c ; Daniel Renčiuka ; c ; Klá ; ra Bedná ; řová ; a ; c ; Iva Kejnovská ; a ; c ; Luká ; &scaron ; Trantí ; rekc ; Michaela Vorlí ; čková ; a ; c ; mifi@ibp.cz" class="auth_mail" title="E-mail the corresponding author ; Janos Sagid ; jans@rimstonelab.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA secondary structure ; Circular dichroism spectroscopy ; Guanine quadruplex ; Base modification ; Oxidative damage
- 刊名：Biochimie
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：118
- 期：Complete
- 页码：15-25
- 全文大小：2737 K
文摘
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Effects of natural lesions formed in human telomere G4 tetrads and loops are reviewed.
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8-oxoG and AP sites formed in G-tetrads significantly destabilize the quadruplex.
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G4 destabilization is more dependent on lesion position than on its type.
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8-oxoA, 5-hmU or AP site in loops affect G4 stability less but can change its folding.
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The effect of loop lesions depends more on the type than on the position in the loop.