Interactions of benzotriazole UV stabilizers with human serum albumin: Atomic insights revealed by biosensors, spectroscopies and molecular dynamics simulations
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- 作者：Shulin Zhuanga ; b ; shulin@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Haifei Wanga ; b ; Keke Dinga ; Jiaying Wanga ; Liumeng Pana ; Yanli Luc ; Qingjun Liuc ; Chunlong Zhangd
- 关键词：Benzotriazole ; Biosensor ; Spectroscopy ; Molecular modeling ; Human serum albumin
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：1050-1059
- 全文大小：2587 K
文摘
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The interaction of BZTs with human serum albumin was deciphered for the first time.
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Fluorescence of human serum albumin was quenched in a concentration-dependent mode.
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BZTs bind at the Sudlow site I site with distinct binding modes.
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Minor changes in the moieties of BZTs may affect their interactions with HSA.
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Our in vitro and in silico approach is helpful to assess risk of BZTs chemicals.