Status epilepticus stimulates NDEL1 expression via the CREB/CRE pathway in the adult mouse brain
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- 作者：Yun-Sik Choia ; Boyoung Leeb ; Katelin F. Hansenc ; Sydney Atenc ; Paul Horningc ; Kelin L. Wheatond ; Soren Impeye ; Kari R. Hoytd ; Karl Obrietanc ; obrietan.1@osu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ChIP ; chromatin immunoprecipitation ; CREB ; cAMP response element-binding protein ; DAB ; diaminobenzidine ; DISC1 ; disrupted in schizophrenia 1 ; GCL ; granule cell layer ; GFP ; green fluorescent protein ; GFAP ; glial fibrillary acidic protein ; Hil ; hilus ; LIS1 ; lissencephaly 1 protein ; NDEL1/NUDEL ; Nuclear distribution element-like 1 ; NF-L ; neurofilament light subunit ; ML ; molecular cell layer ; PBS ; phosphate-buffered saline ; PBST ; PBS with 0.1% Triton-X ; PCL ; pyramidal cell layer ; SE ; status epilepti
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：7 September 2016
- 年：2016
- 卷：331
- 期：Complete
- 页码：1-12
- 全文大小：3401 K
文摘
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Neuronal NDEL1 expression was detected throughout the adult mouse CNS.
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Status epilepticus triggered a lasting increase in NDEL1 in the hippocampus.
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Evoked NDEL1 expression was detected in neurons, but not glia.
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The CREB/CRE transcriptional pathway couples seizure activity to NDEL1 expression.
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Inducible NDEL1 could contribute to seizure-evoked structural and functional plasticity.