The first synthesis of furo[2,3-c]pyridazin-4(1H)-one derivatives

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• 作者：Á ; dá ; m Andor Kelemen ; Balá ; zs Pé ; ter Szabó ; Pé ; ter Ková ; cs ; Gyö ; rgy Mikló ; s Keserű<sup> ; sup><sup>keseru.gyorgy@ttk.mta.hu" class="auth_mail" title="E-mail the corresponding authorsup>
• 关键词：Furo[2 ; 3-c]pyridazin-4(1H)-one ; Medicinal chemistry ; LDA mediated cyclization ; Pyridazin-4(1H)-one condensed ring-system
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：6 January 2016
• 年：2016
• 卷：57
• 期：1
• 页码：64-66
• 全文大小：692 K

文摘

We report a five step method for the synthesis of furo[2,3-c]pyridazin-4(1H)-one derivatives representing a novel heteroaromatic ring-system. The first synthesis of 3-carboxylic and methyl-3-carboxylate derivatives of the 1-phenyl and 1-(p-methoxyphenyl) compounds are reported.