Enantioselective oxidation of racemic 1,2-propanediol to D-(−)-lactic acid by Gluconobacter oxydans

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• 作者：Su ; Wu ; Chang ; Zhiyuan ; Gao ; Keliang ; Wei ; Dongzhi
• 刊名：Tetrahedron: Asymmetry
• 出版年：2004
• 出版时间：April 19, 2004
• 年：2004
• 卷：15
• 期：8
• 页码：1275-1277
• 全文大小：250 K

文摘

Gluconobacter oxydans DSM 2003 was firstly used in the production of (R)-2-hydroxy-propionic acid through microbial oxidation of racemic 1,2-propanediol. The biotransformation was processed with high enantiomeric excess (>99 % ) and near theoretical yield (48 % of racemic 1,2-propanediol) when the substrate concentration was lower than 20g/L. When the substrate concentration was increased, maintaining the pH at 6.0 helped to improve the enantioselectivity.