Selective Persistence of Sensorimotor Mismatch Signals in Visual Cortex of Behaving Alzheimer’s Disease Mice
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- 作者：Sabine Liebscher1 ; 2 ; 3 ; sabine.liebscher@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Georg B. Keller1 ; 4 ; Pieter M. Goltstein1 ; Tobias Bonhoeffer1 ; Mark Hü ; bener1 ; mark@neuro.mpg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：APP/PS1 ; two-photon calcium imaging ; sensorimotor integration ; visual cortex ; GCaMP
- 刊名：Current Biology
- 出版年：2016
- 出版时间：4 April 2016
- 年：2016
- 卷：26
- 期：7
- 页码：956-964
- 全文大小：3350 K
文摘
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Visually driven and motor-related activity in V1 is reduced in behaving AD tg mice
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Aberrant activity during quiescent states is increased in behaving AD tg mice
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Visuomotor mismatch signals are selectively spared in AD tg mice
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Coding accuracy of the network is degraded in AD tg mice