- 作者：Susann Bl眉her ; David Petroff ; Antje Wagner ; Katja Warich ; Ruth Gausche ; Thorsten Klemm ; Mario Wagner ; Alex ; ra Keller
- 关键词：ALAT ; alanine aminotransferase ; ASAT ; aspartate aminotransferase ; BF ; body fat ; BMI ; body mass index ; FI ; fasting insulin ; GGT ; gamma glutamyl transferase ; HDL ; high density lipoprotein cholesterol ; HOMA-IR ; homeostasis model assessment of insulin resistance ; ITT ; intend to treat ; KLAKS ; Concept Leipzig ; Adiposity therapy for school aged children ; LDL ; low density lipoprotein cholesterol ; OGTT ; oral glucose tolerance test ; PP ; per protocol ; SDS ; standard deviation score ; SE ; standard error ; UA
- 刊名：Metabolism
- 出版年：March, 2014
- 年：2014
- 卷：63
- 期：3
- 页码：422-430
- 全文大小：587 K
Objective
Regular physical exercise within structured lifestyle programs may improve weight status and minimize metabolic risk factors in childhood obesity. The aim of this study was to evaluate the effect of the one-year combined physical exercise/lifestyle program KLAKS on anthropometric and metabolic parameters and glycemic control in childhood obesity.Materials and Methods
142 overweight/obese (BMI > 90th percentile) candidates (7-18 years) were enrolled, 115 participants completed the program. Anthropometrics and biochemical parameters were obtained at beginning and completion. An oral glucose tolerance test (OGTT) was performed in a subgroup of participants. Course of glucose and insulin levels within OGTT was correlated with several parameters and is reported here for those who completed the program.
Results
The mean standard deviation scores (SDS) decreased significantly for BMI, waist circumference, waist-to-height ratio (WHtR) and percentage body fat (all p 鈮?#xA0;0.01). Improved metabolic risk markers included mean glucose levels within an OGTT at follow-up compared to baseline (p < 0.0001) and HbA1c (p = 0.05) as well as indications of improvement for gamma-glutamyl-transferase and free fatty acids.
Conclusions
The one-year combined exercise/lifestyle program KLAKS significantly improves markers of obesity and glycemic control. Impaired cardiometabolic risk markers, even subclinical, are also favorably influenced by program participation.