Central regions of keloids are severely ischaemic

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• 作者：Ryoma Touchi^a ; ^{ryo_0623_ma@yahoo.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Koichi Ueda^a ; Norifumi Kurokawa^b ; Motomu Tsuji^c
• 关键词：Keloid ; Ischaemia ; Hypoxia-induced factor 1α ; Vascular endothelial growth factor
• 刊名：Journal of Plastic, Reconstructive & Aesthetic Surgery
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：69
• 期：2
• 页码：e35-e41
• 全文大小：731 K

文摘

We classified scars as keloids, hypertrophic scars and mature scars, and then examined the scars for differences in central and marginal vascularization. We found significant differences in localized hypoxia-induced factor-1α (HIF-1α) expression and vascular density in keloids, but no localized differences in hypertrophic or mature scars. The central areas of keloids exhibited higher HIF-1α expression and lower vascular density than marginal areas, suggesting that the former are severely ischaemic.