Keloids are dermal tumors characterized by excessive accumulation of collagen.
The key cell responsible for matrix production is activated myofibroblast.
A number of growth factors, particularly TGF-β, play a role in excessive collagen production.
Recent studies have supported a role for Fibronectin Extra Domain A (Fn-EDA) which is markedly upregulated in keloids.
Identification of pathways involved in matrix accumulation allows development of targeted therapies for fibrotic diseases.