Identification of potent pyrimidine inhibitors of phosphodiesterase 7
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- 作者：Junqing Guo ; Andrew Watson ; James Kempson ; Marianne Carlsen ; Joseph Barbosa ; Karen Stebbins ; Deborah Lee ; John Dodd ; Steven G. Nadler ; Murray McKinnon ; Joel Barrish ; William J. Pitts
- 关键词：Pyrimidine ; Phosphodiesterase 7 ; T cell
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2009
- 出版时间：1 April 2009
- 年：2009
- 卷：19
- 期：7
- 页码：1935-1938
- 全文大小：590 K
文摘
A series of pyrimidine based inhibitors of PDE7 are discussed. The synthesis, structure–activity relationships (SAR) and selectivity against several other PDE family members as well as activity in T cells are presented. These compounds were found to have effects on T cell proliferation, however it is not clear whether the mechanism is related to PDE7 inhibition.