Association between pentraxin 3 levels and aortic valve calcification

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• 作者：Kenji Norimatsu ; MD^a ; Shin-ichiro Miura ; MD ; FJCC^a ; ^b ; ^{miuras@cis.fukuoka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Yasunori Suematsu ; MD^a ; Yuhei Shiga ; MD^a ; Yuiko Miyase ; MD^a ; Ayumi Nakamura ; MD^a ; Bo Zhang ; PhD^c ; Keijiro Saku ; MD ; FJCC^a ; ^b
• 关键词：Pentraxin 3 ; Aortic valve calcification ; Aortic valve sclerosis ; Aortic valve stenosis ; Coronary computed tomography angiography
• 刊名：Journal of Cardiology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：68
• 期：1
• 页码：76-82
• 全文大小：871 K

文摘

Aortic valve calcification (AVC) reflects the state of aortic valve sclerosis (AVS), which is a precursor to aortic valve stenosis (AS). Therefore, we investigated the presence of AVC in patients who underwent coronary computed tomography angiography (CTA), which is an effective tool for evaluating early-stage AVC, and examined the association between plasma levels of pentraxin 3 (PTX3) and AVC.

Methods and results

The subjects consisted of 162 consecutive patients who underwent CTA and in whom we could measure plasma levels of PTX3. We divided the patients into an AVC group (n = 42) and a non-AVC group (n = 120), as assessed by CT. Furthermore, we divided the patients without AS, assessed by echocardiography, into non-AS AVC (n = 23) and non-AS non-AVC groups (n = 60). We analyzed the predictors of the presence of AVC in all patients by a logistic regression analysis. AVC was independently associated with PTX3, in addition to age, chronic kidney disease, and coronary artery calcification. We also examined the predictors of the presence of AVC in patients without AS. PTX3, in addition to age, was an independent predictor of the presence of AVC in patients without AS. Finally, we found that adding PTX3 to the model containing age improves the specificity and, therefore, positive predictive value for AVC.

Conclusions

PTX3, in addition to age, was shown to be an independent predictor of AVC in patients without AS. The combination of age and PTX3 may be a better approach to the evaluation of AVC than either of these alone.