Type II cGMP-dependent protein kinase negatively regulates fibroblast growth factor signaling by phosphorylating Raf-1 at serine 43 in rat chondrosarcoma cells

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• 作者：Norio Kamemura^a ; Sara Murakami^b ; Hiroaki Komatsu^b ; Masahiro Sawanoi^b ; Kenji Miyamoto^b ; Kazumi Ishidoh^c ; Koji Kishimoto^a ; Akihiko Tsuji^a ; ^b ; Keizo Yuasa^a ; ^b ; ^{kyuasa@tokushima-u.ac.jp}
• 关键词：PKGII ; Raf-1 ; Chondrocytes ; FGF
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：82-87
• 全文大小：822 K
• 卷排序：483

文摘

Ser-43 of Raf-1 was phosphorylated by cGMP treatment in rat chondrosarcoma cells. Forskolin stimulated the phosphorylation of Raf-1 at Ser-259 in addition to Ser-43. PKGII phosphorylated Raf-1 at Ser-43 in a cGMP-dependent manner. Phosphorylation of Raf-1 at Ser-43 suppressed FGF2-induced MAPK activation.