Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways
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- 作者：Javier Rodriguez1 ; 3 ; Ruth Pilkington1 ; Amaya Garcia Munoz1 ; Lan K. Nguyen1 ; Nora Rauch1 ; Susan Kennedy1 ; Naser Monsefi1 ; Ana Herrero1 ; Cormac T. Taylor1 ; 2 ; Alex von Kriegsheim1 ; 3 ; alex.vonkriegsheim@igmm.ed.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：22 March 2016
- 年：2016
- 卷：14
- 期：11
- 页码：2745-2760
- 全文大小：4740 K
文摘
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The proteomic screen for FIH and PHD3 substrates identifies numerous interactors
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Potential substrates are enriched in numerous hypoxia-regulated pathways
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FIH regulates RIPK4 kinase activity by direct hydroxylation
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Hydroxylation of Pro25 by PHD3 regulates MAPK6 (Erk3) protein stability