A mathematical model for the role of N2O3 in enhancing nitric oxide bioavailability following nitrite infusion
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- 作者：Yien Liu ; Donald G. Buerk ; Kenneth A. Barbee ; Dov Jaron ; dov.jaron@drexel.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nitrite infusion ; Nitrous anhydride ; Dinitrogen trioxide ; Arteriole ; Hypoxic vasodilation
- 刊名：Nitric Oxide
- 出版年：2016
- 出版时间：30 November 2016
- 年：2016
- 卷：60
- 期：Complete
- 页码：1-9
- 全文大小：1185 K
文摘
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The N2O3 pathway enhances NO availability from hemoglobin nitrite reductase.
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Hypoxia and moderate levels of nitrite are required to produce significant nitric oxide.
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This nitric oxide enhancing mechanism is consistent at different blood flow rates.
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This model does not fully explain how low nitrite levels can cause vasodilation.