Undifferentiated murine embryonic stem cells used to model the effects of the blue-green algal toxin cylindrospermopsin on preimplantation embryonic cell proliferation
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- 作者：Katherine J. Reida ; c ; Kenneth Langa ; b ; Suzanne Frosciob ; Andrew J. Humpagec ; Fiona M. Younga ; d ; Fiona.Young@flinders.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cylindrospermopsin ; Mouse embryonic stem cell ; Neural differentiation ; Crystal violet cytotoxicity assay ; Embryonic development
- 刊名：Toxicon
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：106
- 期：Complete
- 页码：79-88
- 全文大小：1115 K
文摘
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72 h exposure to drinking water CYN guideline 1 渭g/L did not affect mES proliferation.
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1 渭g/L CYN did not affect mES differentiation.
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High algal bloom CYN toxin levels have potential for preimplantation toxicity.
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Australian Drinking Water CYN guideline 1 渭g/L likely to be ‘safe’ for early embryos.
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Embryonic stem cell assay has broad application to screening environmental toxins.