Post-translational regulation of PTEN catalytic function and protein stability in the hibernating 13-lined ground squirrel
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- 作者：Cheng-Wei Wu1 ; Ryan A. Bell ; Kenneth B. Storey ; kenneth_storey@carleton.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Insulin signaling pathway ; Ground squirrels ; Hibernation ; Protein phosphatase ; Phosphorylation
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：1850
- 期：11
- 页码：2196-2202
- 全文大小：557 K
文摘
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Non-phosphorylated PTEN protein is elevated during torpor.
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Catalytic activity of PTEN is elevated during torpor, with reduced protein stability.
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PTEN phosphorylation site overlaps with PEST motifs that regulate protein stability.
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PTEN activation during torpor is associated with decreased PDK-1 phosphorylation.