Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis
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- 作者：Xinjian Li1 ; Yuhui Jiang1 ; 2 ; Jill Meisenhelder3 ; Weiwei Yang1 ; David H. Hawke4 ; Yanhua Zheng1 ; Yan Xia1 ; 2 ; Kenneth Aldape4 ; Jie He5 ; Tony Hunter3 ; Liwei Wang2 ; Zhimin Lu1 ; 6 ; 7 ; zhiminlu@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：PGK1 ; PDHK1 ; PDH ; mitochondria ; phosphorylation ; glycolysis ; hypoxia ; EGFR ; K-Ras ; B-Raf ; tumorigenesis
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：3 March 2016
- 年：2016
- 卷：61
- 期：5
- 页码：705-719
- 全文大小：5151 K
文摘
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ERK and PIN1 regulate mitochondrial translocation of PGK1
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PGK1, acting as a protein kinase, phosphorylates and activates PDHK1
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PGK1 suppresses ROS production and coordinates glycolysis and the TCA cycle
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Mitochondrial PGK1 promotes tumor cell proliferation and brain tumorigenesis