Chronic Inflammatory Disease Is an Independent Risk Factor for Coronary Flow Velocity Reserve Impairment Unrelated to the Processes of Coronary Artery Calcium Deposition

详细信息    查看全文

• 作者：Kentaro Kakuta ; MD^a ; ^c ; Kaoru Dohi ; MD ; PhD^c ; ^{dohik@clin.medic.mie-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Yoshiko Sato ; MD ; PhD^b ; Takashi Yamanaka ; MD ; PhD^a ; Masaki Kawamura ; MD ; PhD^a ; Toru Ogura ; PhD^e ; Shiro Nakamori ; MD ; PhD^c ; Naoki Fujimoto ; MD ; PhD^d ; Eitaro Fujii ; MD ; PhD^c ; Norikazu Yamada ; MD ; PhD^c ; Masaaki Ito ; MD ; PhD^c
• 关键词：Chronic inflammatory disease ; Coronary microvascular dysfunction ; Coronary flow velocity reserve ; Coronary artery calcium score
• 刊名：Journal of the American Society of Echocardiography
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：29
• 期：2
• 页码：173-180
• 全文大小：535 K

文摘

Chronic inflammatory disease (CID) is a complex multisystem disease characterized by chronic inflammation, which can lead to coronary microvascular dysfunction (CMD) and can also predispose to coronary artery calcium deposition, even in the absence of obstructive coronary artery disease.

Methods

Twenty-one patients with systemic lupus erythematosus (SLE; mean age, 60 ± 11 years), 21 patients with systemic sclerosis (SSc; mean age, 66 ± 11 years), 32 patients with rheumatoid arthritis (RA; mean age, 65 ± 9 years), and 23 control subjects with comparable traditional risk factors for coronary artery disease (mean age, 65 ± 10 years) were prospectively enrolled in the outpatient clinic. All study participants underwent transthoracic Doppler-derived echocardiography for coronary flow velocity reserve (CFVR) measurement in the left anterior descending coronary artery; CFVR < 2.5 defined CMD. Coronary artery calcium score in the left anterior descending coronary artery was also assessed by computed tomography.

Results

None of study participants had obstructive coronary artery disease. The prevalence of CMD was 26% in the control group, 67% in the SLE group, 76% in the SSc group, and 63% in the RA group (P < .05, CID groups vs control group). CFVR was significantly lower in all three CID groups than in the control group (control group, 3.01 ± 0.72; SLE group, 2.23 ± 0.71; SSc group, 2.14 ± 0.54; RA group, 2.33 ± 0.62; P < .05, CID groups vs control group). In contrast, coronary artery calcium scores were similar in the four groups and had no relation to CMD. The odds ratios for CMD in patients with SLE, SSc, and RA were 16.70, 25.78, and 8.44 (P < .05) after adjusting for age, body mass index, the presence or absence of anemia, and hemoglobin level. Multiple linear regression analysis showed that only the presence of CID was independently associated with reduced CFVR among all study participants.

Conclusions

CID strongly contributes to CMD identified by qualitative evaluation of CFVR independently of traditional coronary risk factors of atherosclerosis but does not predispose to coronary artery calcification.