Down-regulation of cell adhesion via rho-associated protein kinase (ROCK) pathway promotes tumor cell migration on laminin-511
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- 作者：Yamato Kikkawa ; kikkawa@toyaku.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Nozomi Harashima ; Kazuki Ikari ; Shogo Fujii ; Fumihiko Katagiri ; Kentaro Hozumi ; Motoyoshi Nomizu
- 关键词：Cell adhesion ; Cell migration ; Basement membrane ; Integrin ; Laminin
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：344
- 期：1
- 页码：76-85
- 全文大小：2212 K
文摘
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PMA-stimulation significantly promotes tumor cell migration on laminin-511 (LM-511).
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Cell migration is associated with weakened cell adhesion to LM-511 via integrin α3β1.
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ROCK signaling pathway modulates tumor cell migration on LM-511.