Effects of parity and gestational age on second-trimester induction-abortion interval in combination with osmotic dilators and gemeprost

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• 作者：Kentaro Kai ; Shinya Karakida ; Michiharu Kono ; Toshio Sasaki ; Kazumi Togo ; Akitoshi Tsuno ; Yoshihiro Nishida ; Hisashi Narahara
• 关键词：Induction&ndash ; abortion interval ; Second trimester ; Medical abortion ; Gemeprost ; Gestational age ; Parity
• 刊名：Contraception
• 出版年：2012
• 出版时间：August, 2012
• 年：2012
• 卷：86
• 期：2
• 页码：147-152
• 全文大小：547 K

文摘

Background

The true prognostic factors for induced medical abortion are unknown. We sought to investigate the effects of a patient's obstetric parameters on the induction-abortion interval in second-trimester medical abortion.

Study Design

We studied 216 consecutive women. Pregnancy was terminated with cervical preparation using osmotic dilators followed by 1 mg vaginal gemeprost administered every 3 h for a maximum of five doses in the first 24 h. All variables are expressed in categorical form (parity, gestational age, maternal age and body mass index) and analyzed by the Cox proportional hazards model.

Results

Parity ¡Ý3 was associated with a shorter duration of the induction-abortion interval (adjusted hazards ratio 1.96; 95 % confidence interval 1.13-3.40). A gestational age ¡Ý16 weeks was associated with a longer duration of the induction-abortion interval (0.71; 0.52-0.98). No significant association was found in maternal age and body mass index.

Conclusions

In combination with osmotic dilators and gemeprost, gestational age and parity are independent factors that affected the induction to abortion interval of second-trimester medical abortion.