Extremely Long-Range Chromatin Loops Link Topological Domains to Facilitate a Diverse Antibody Repertoire
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- 作者：Lindsey Montefiori1 ; 6 ; Robert Wuerffel2 ; 6 ; Damian Roqueiro3 ; Bryan Lajoie4 ; Changying Guo1 ; Tatiana Gerasimova1 ; Supriyo De5 ; William Wood5 ; Kevin G. Becker5 ; Job Dekker4 ; Jie Liang3 ; Ranjan Sen1 ; 7 ; senranja@grc.nia.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Amy L. Kenter2 ; 7 ; star1@uic.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：2 February 2016
- 年：2016
- 卷：14
- 期：4
- 页码：896-906
- 全文大小：2148 K
文摘
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Igh locus contraction occurs in pro-B cells prior to VDJ joining
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Pro-B cell-specific chromatin looping at the multi-megabase scale defines locus contraction
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A subset of these exceptionally long chromatin loops are Pax5 dependent
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VH gene rearrangement is dependent upon independently regulated chromatin topologies