Diabetes and ageing in the Melbourne Collaborative Cohort Study (MCCS)

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• 作者：Allison M. Hodge^a ; ^{allison.hodge@cancervic.org.au} ; Leon Flicker^b ; ^c ; ^d ; Kerin O&rsquo ; Dea^e ; Dallas R. English^a ; ^f ; Graham G. Giles^a
• 关键词：BMI ; body mass index ; WHR ; waist to hips ratio ; MCCS ; Melbourne Collaborative Cohort Study ; SEIFA ; Socio-Economic Indexes For Areas
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：100
• 期：3
• 页码：398-403
• 全文大小：514 K

文摘

Aims

To examine the association between diabetes, and ageing 12 years later.

Methods

Subjects reporting angina, cancer, heart attack or stroke at baseline (1990-1994) were excluded. Diabetes at baseline was identified by self-report or elevated plasma glucose (¡Ý7.0 mmol/l fasting or ¡Ý11.1 mmol/l non-fasting). 6431 eligible men and women had survived to age 70 years at follow-up (2003-2007), and 5704 with complete data were included in these analyses. Those without ischemic heart disease, stroke, and cancer, no perceived major difficulty with physical functioning, and no evidence of psychological distress were considered to have aged successfully, irrespective of diabetes at follow-up (n = 1271). Logistic regression was used to examine the independent association between baseline diabetes and successful ageing.

Results

At baseline 216 eligible people were identified with diabetes. This was inversely associated with successful ageing at follow-up independent of smoking, physical activity, alcohol use and obesity (OR 0.65, 95 % 0.42-0.99), Of the people with diabetes at follow-up, only 12.5 % did not have another condition characteristic of usual ageing, compared with 22.7 % of people who did not have diabetes.

Conclusions

Diabetes is strongly associated with factors characterising less successful ageing, suggesting that the impact of diabetes may be larger than currently estimated.