Significant IFNγ responses of CD8+ T cells in CMV-seropositive individuals with autoimmune arthritis
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- 作者：Giovanni Almanzara ; Almanzar_G@ukw.de" class="auth_mail" title="E-mail the corresponding author ; Marc Schmalzingb ; Raimund Trippena ; Kerstin Hö ; fnera ; Benedikt Weiß ; brichc ; Eva Geissingerd ; Thomas Meyere ; Johannes Liesea ; Hans-Peter Tonyb ; Martina Preloga
- 关键词：CMV ; JIA ; RA ; IFNγ ; Anti-TNFα ; Anti-IL-6
- 刊名：Journal of Clinical Virology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：77-84
- 全文大小：1656 K
文摘
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CMV accelerates the signs of premature immunosenescence in JIA and RA patients.
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CD69 and Ki67 expression in CD8+ T-cells is low in RA patients compare to age-matched controls.
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CD28-CD8+ T-cells may control latent CMV infection regarless in vitro blockade of TNFα or IL-6 in CMV+ RA patients.