Possible role of PGD₂ in malaria infections

详细信息    查看全文

• 作者：Pimwan Thongdee¹ ; Jiraporn Kuesap² ; Raewadee Wisedpanichkij³ ; Kesara Na-Bangchang¹ ; ⁴ ; ^{kesaratmu@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Malaria ; Plasmodium vivax ; Plasmodium falciparum ; Prostaglandin D2 (PGD2) ; Malaria severity
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：9
• 期：9
• 页码：856-859
• 全文大小：268 K

文摘

To preliminarily investigate the possible role of prostaglandin D₂ (PGD₂) in malaria infections.

Methods

Blood and urinary samples (m>nm> = 120 each) were collected from Thai patients with m>Plasmodium falciparumm> (m>P. falciparumm>) with moderate (m>nm> = 26) and high (m>nm> = 4) parasitemia, patients with m>Plasmodium vivaxm> (m>P. vivaxm>) (m>nm> = 30), patients with fever associated with other infections (m>nm> = 30), and healthy subjects (m>nm> = 30). PGD₂ concentrations in plasma and urinary samples of healthy subjects, patients with fever associated with other infections and patients with malaria were determined using Prostaglandin D₂-MOX express EIA kit (Cayman Chemical, USA).

Results

The possible association between PGD₂ and malaria infections is clearly demonstrated with PGD₂ concentration in urine. The urinary PGD₂ concentrations were relatively high (about 5-fold) in patients with m>P. falciparumm> with moderate parasitemia and m>P. vivaxm> infections compared with other groups. Furthermore, the concentration in patients with m>P. falciparumm> with moderate parasitemia and m>P. vivaxm> infection were significantly higher than that in healthy subjects and patients with fever associated with other infections.

Conclusions

Urinary PGD₂ concentrations may offer a more dependable and useful tool for predicting malaria severity. Confirmation is this preliminary finding is required with a larger sample size.