In vitro sensitivity of antimalarial drugs and correlation with clinico-parasitological response following treatment with a 3-day artesunate-mefloquine combination in patients with falciparum malaria along the Thai-Myanmar border

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• 作者：Phunuch Muhamad^a ; Artitaya Thiengsusuk^a ; Papichaya Phompradit^b ; Kesara Na-Bangchang^b ; ^{kesaratmu@yahoo.com}
• 关键词：Plasmodium falciparum ; Artemisinin combination therapy ; Treatment response ; in vitro sensitivity test ; Antimalrial drug resistance
• 刊名：Acta Tropica
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：166
• 期：Complete
• 页码：257-261
• 全文大小：632 K
• 卷排序：166

文摘

The parasite clearance time (PCT) in patients with ‘Late Parasitological Response’ was significantly prolonged compared with ‘Adequate Parasitological Response’ and re-infection. Declining in vitro artesunate and mefloquine sensitivity has been observed in Plasmodium falciparum isolates collected from ‘Late Parasitological Failure (LPF)’ patients compared to ‘Adequate Clinical and Parasitological Response (ACPR)’, and re-infection. The correlation between in vitro sensitivity of Plasmodium falciparum isolates to artesunate and PCT suggests that the in vitro susceptibility information is a reliable tool to predict clinico-parasitological response following a 3-day artesunate-mefloquine.