Association between delivery of a small-for-gestational-age neonate and long-term maternal cardiovascular morbidity

详细信息    查看全文

• 作者：Gali Pariente ; Eyal Sheiner ; Roy Kessous ; Sherf Michael ; Ilana Shoham-Vardi
• 关键词：Cardiovascular ; Maternal mortality ; Morbidity ; Small for gestational age
• 刊名：International Journal of Gynecology and Obstetrics
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：123
• 期：1
• 页码：68-71
• 全文大小：210 K

文摘

Objective

To investigate whether delivering a small-for-gestational-age (SGA) newborn is a risk factor for subsequent long-term maternal cardiovascular morbidity.

Methods

Data were analyzed from consecutive pregnant women who delivered at Soroka University Medical Center, Beer-Sheva, Israel, between 1988 and 1999, and were followed-up retrospectively until 2010. Long-term cardiovascular morbidity was compared among women with and without SGA neonates.

Results

During the study period, 47 612 deliveries met the inclusion criteria, and 4411 (9.3 % ) women delivered an SGA neonate. Delivery of an SGA neonate was a risk factor for long-term complex cardiovascular events, including congestive heart failure, hypertensive heart and kidney disease, and acute cor pulmonale (odds ratio [OR], 2.3; 95 % confidence interval [CI], 1.3-4.4; P = 0.006); and long-term cardiovascular mortality (OR, 3.4; 95 % CI, 1.5-7.6; P = 0.006). Women who delivered an SGA neonate had a significantly higher risk for cardiovascular mortality during the follow-up period (Kaplan-Meier survival analysis, P = 0.002). Delivery of an SGA neonate remained an independent risk factor for long-term maternal cardiovascular mortality (Cox multivariable regression: adjusted hazard ratio, 3.5; 95 % CI, 1.5-8.2; P = 0.004).

Conclusion

Delivery of an SGA neonate is an independent risk factor for long-term cardiovascular morbidity in a follow-up period of more than 10 years.