Dietary alpha-ketoglutarate increases cold tolerance in Drosophila melanogaster and enhances protein pool and antioxidant defense in sex-specific manner
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- 作者：Maria M. Bayliaka ; bayliak@ukr.net" class="auth_mail" title="E-mail the corresponding author ; Maria P. Lylyka ; Halyna V. Shmihela ; Oksana M. Sorochynskaa ; Oksana V. Manyukha ; Stefan G. Pierzynowskib ; c ; Volodymyr I. Lushchaka ; lushchak@pu.if.ua" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABTS ; 2 ; 2&prime ; -azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt ; AKG ; alpha-ketoglutarate ; H-SH ; high molecular mass thiol groups ; KPi ; potassium phosphate buffer ; L-SH ; low molecular mass thiol groups ; ROS ; reactive oxygen species ; TAC ; total antioxidant capacity ; TCA ; trichloroacetic acid
- 刊名：Journal of Thermal Biology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：60
- 期：Complete
- 页码：1-11
- 全文大小：1458 K
文摘
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Dietary alpha-ketoglutarate (AKG) increases cold tolerance in adult D. melanogaster flies.
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AKG enhances locomotor capability in male flies.
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AKG provides higher levels of total free amino acids and proline in female flies.
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AKG enhances total antioxidant capacity in flies of both sexes.
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AKG protects males and females from cold stress by partly different mechanisms.