α-Trifluoromethyl-β-aryl enamines in the synthesis of trifluoromethylated heterocycles by the Fischer and the Pictetȁ3;Spengler reactions

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• 作者：Vasiliy M. Muzalevskiy ; Valentine G. Nenajdenko ; Aleksey V. Shastin ; Elizabeth S. Balenkova ; Gü ; nter Haufe
• 关键词：&#x3b1 ; -Trifluoromethyl-&#x3b2 ; -aryl enamines ; Fischer indole synthesis ; Pictetȁ3 ; Spengler reaction ; Indoles ; Tetrahydropyridines ; Carbolines
• 刊名：Tetrahedron
• 出版年：2009
• 出版时间：5 September 2009
• 年：2009
• 卷：65
• 期：36
• 页码：7553-7561
• 全文大小：357 K

文摘

α-Trifluoromethyl-β-aryl enamines were successfully used as synthetic equivalents of benzyltrifluoromethyl ketones in both the Fischer indole synthesis and the Pictetȁ3;Spengler reaction. Accordingly, 2-trifluoromethyl indoles and a variety of trifluoromethylated 4,5,6,7-terahydro-1H-pyridines including carbolines were synthesized in moderate to good yields.