Base-promoted domino reaction for the synthesis of 2,3-disubstituted indoles from 2-aminobenzaldehyde/2-amino aryl ketones, tosylhydrazine, and aromatic aldehydes

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• 作者：Yan-Dong Wu ; ^{chwuyd@mail.ccnu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Jun-Rui Ma ; Wen-Ming Shu ; Kai-Lu Zheng ; An-Xin Wu ; ^{chwuax@mail.ccnu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：2 ; 3-Disubstituted indoles ; Base-promoted domino reaction ; 2-Aminobenzaldehyde/2-amino aryl ketones ; Tosylhydrazine ; Aromatic aldehydes
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：11 August 2016
• 年：2016
• 卷：72
• 期：32
• 页码：4821-4826
• 全文大小：761 K

文摘

A base-promoted domino reaction to synthesize the 2,3-disubstituted indoles from 2-aminobenzaldehyde/2-amino aryl ketones, tosylhydrazine, and aromatic aldehydes has been developed. This strategy provides a simple and beneficial way for the construction of 2,3-disubstituted indole compounds from readily available starting materials under mild conditions.