Enantioselective hydrogenation of ketopantolactone using Pt–β-ICN chiral catalyst: Correlation between the solution-state concentration of a nucleophilic β-isocinchonine–ketopantolactone complex and enantioselectivity
详细信息 查看全文
- 作者：Tamá ; s A. Martinek ; Tibor Varga ; Katalin Balá ; zsik ; Gyö ; rgy Szö ; llő ; si ; Ferenc Fü ; lö ; p ; Mihá ; ly Bartó ; k
- 关键词：Pt– ; cinchona catalyst ; Enantioselective hydrogenation ; Intermediate complex ; Ketopantolactone ; NMR ; Origin of enantioselection ; Organocatalysis
- 刊名：Journal of Catalysis
- 出版年：2008
- 出版时间：25 April 2008
- 年：2008
- 卷：255
- 期：2
- 页码：296-303
- 全文大小：468 K
文摘
Experimental evidence (measured by NMR) is given for the correlation between the solution-state concentration of the nucleophilic 1:1 modifier–substrate complex and the ee on enantioselective hydrogenation of ketopantolactone using Pt–β-isocinchonine chiral catalyst. The relationship displays a saturation-type curve, which may indicate an underlying adsorption process involving the catalytically relevant nucleophilic complex.