Developmental pharmacokinetics and pharmacodynamics of parenteral opioids and nonsteroidal anti-nflammatory drugs in neonates and infants

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• 作者：Lizabeth Martin ; ^{Lizabeth.martin@seattlechildrens.org} ; Nathalia Jimenez ; Anne M. Lynn
• 关键词：Infant ; Infant care ; Analgesics ; opioid ; Pharmacokinetics ; Pharmacology
• 刊名：Colombian Journal of Anesthesiology
• 出版年：2017
• 出版时间：January-March 2017
• 年：2017
• 卷：45
• 期：1
• 页码：72-79
• 全文大小：902 K
• 卷排序：45

文摘

Pharmacology of infants is understudied and different from other populations.ObjectiveTo review the unique features of neonatal and infant physiology that impact drug handling and the pharmacokinetics of analgesics, including opioids, ketorolac and acetaminophen.Materials and methodsThis article is a narrative review of the literature from the authors' point of view that constitutes a summary of the information presented at the annual Colombian Society for Anesthesia meeting in Cali, Colombia June 2015.ConclusionsPharmacology in neonates and infants is unique and must be considered in this vulnerable population. Recommendations for administration of these analgesics are presented based on their unique pharmacokinetic properties. Individual patient variation and clinical response must also be taken into account.