α-Fluorination of β-ketosulfones by Selectfluor™ F–TEDA–BF4
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- 作者：Hossein Loghmani-Khouzani ; Mohammad R. Poorheravi ; Majid M.M. Sadeghi ; Lorenzo Caggiano ; Richard F.W. Jackson
- 关键词：Fluorination ; Selectfluor™ ; β ; -Ketosulfones ; Difluoromethylene
- 刊名：Tetrahedron
- 出版年：2008
- 出版时间：21 July 2008
- 年：2008
- 卷：64
- 期：30-31
- 页码：7419-7425
- 全文大小：282 K
文摘
Attempted fluorination of β-ketosulfides using Selectfluor™ resulted only in the isolation of the corresponding diaryl disulfides, presumed to arise by decomposition of an unstable fluorinated intermediate. However, fluorination of β-ketosulfones using Selectfluor™ under anhydrous conditions does allow the isolation of both mono-and difluorinated products in moderate to good yields.