Fe(OTf)₃-mediated synthesis of sulfonyl dihydropyrans

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• 作者：Meng-Yang Chang ; ^{mychang@kmu.edu.tw" class="auth_mail" title="E-mail the corresponding author} ; Yu-Hsin Chen ; Yu-Chieh Cheng
• 关键词：Sulfonyl dihydrofurans ; β-Ketosulfones ; Prenyl alcohol
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：28 January 2016
• 年：2016
• 卷：72
• 期：4
• 页码：518-524
• 全文大小：924 K

文摘

Fe(OTf)₃-mediated one-pot (3+3) cycloaddition of β-ketosulfones 1 with prenyl alcohol (2) in MeNO₂ affords sulfonyl dihydropyrans 5 in good yields via a sequential intermolecular α-prenylation followed by intramolecular Friedel–Crafts alkylation. The method provides a highly effective condition.