Synthesis of substituted 2-vinylfurans

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• 作者：Chieh-Kai Chan ; Yi-Ju Lu ; Meng-Yang Chang ; ^{mychang@kmu.edu.tw" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Vinylfurans ; Cycloisomerization ; β-Ketosulfones
• 刊名：Tetrahedron
• 出版年：2015
• 出版时间：23 December 2015
• 年：2015
• 卷：71
• 期：51
• 页码：9544-9549
• 全文大小：615 K

文摘

K₂CO₃ (3a)-mediated (3+2) cycloisomerization of β-ketosulfones 1 with 1,4-dichloro-2-butyne (2) in acetone afforded substituted 2-vinylfurans 4 at 56 °C for 8 h in good yields. The one-pot tandem route provides mild, facile and efficient reaction conditions. A plausible mechanism has been discussed and proposed.