- 作者：Ya Li Jin ; Tong Zhu ; Lin Xu ; Wei Sen Zhang ; Bin Liu ; Chao Qiang Jiang ; Hong Yu ; Li Ming Huang ; Kar Keung Cheng ; G. Neil Thomas ; Tai Hing Lam
- 关键词：Uric acid ; Cardiovascular risk ; Hyperuricemia ; Diabetes
- 刊名：International Journal of Cardiology
- 出版年：2013
- 出版时间：3 October, 2013
- 年：2013
- 卷：168
- 期：3
- 页码：2238-2241
- 全文大小：163 K
Objective
To examine the association between serum uric acid (UA) levels and cardiovascular risk factors in subjects without diabetes or hyperuricemia.Methods
6172 women and 2662 men aged 50 + years without diabetes from Phase 1 of the Guangzhou Biobank Cohort Study were included. Data on personal history, physical examination and biochemical parameters were collected. Subjects were categorized by serum UA concentration, and the association between UA levels and cardiovascular risk factors was examined using generalized linear models.
Results
In both men and women with normouricemia (UA < 420 ¦Ìmol/l in men and < 360 ¦Ìmol/l in women), tertiles of UA levels were adversely associated with body mass index, waist circumference, waist-to-hip ratio, total- and HDL-cholesterol, apolipoprotein A1, systolic and diastolic blood pressures, pulse pressure, fasting plasma glucose and white blood cell count (P value for trend ranged from 0.04 to < 0.001), and also consistently associated with metabolic disorders including obesity, hypertension, hypertension treatment, dyslipidemia, waist circumference increased since the age of 18 years and the metabolic syndrome (P value for trend ranged from 0.02 to < 0.001).
Conclusion
Increasing UA levels, even in subjects with normouricemia and without diabetes, were associated with increasing prevalence of cardiovascular risk factors, suggesting that clinically dichotomous definition of hyperuricemia may be inadequate and high-normal value of UA may warn of metabolic disorders.