Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6Clow Monocytes while Preserving Macrophage Gene Function
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The m>Nr4a1m> enhancer domain regulates Ly6Clow monocyte development

E2 domain-deficient resident tissue macrophages show wild-type m>Nr4a1m> expression

E2 domain-deficient macrophages respond normally to LPS stimulation

KLF2 acts via E2 to regulate m>Nr4a1m> in Ly6Clow monocyte development

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