Development of a translational model to screen medications for cocaine use disorder II: Choice between intravenous cocaine and money in humans
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- 作者：Joshua A. Lilea ; b ; c ; jalile2@email.uky.edu" class="auth_mail" title="E-mail the corresponding author ; William W. Stoopsa ; b ; c ; Craig R. Rusha ; b ; c ; S. Stevens Negusd ; Paul E.A. Glaserc ; e ; Kevin W. Hattonf ; g ; Lon R. Haysc ; h
- 关键词：Reinforcing effects ; Subjective effects ; Cardiovascular ; Choice ; Reverse translation ; Monkey ; Progressive-ratio
- 刊名：Drug and Alcohol Dependence
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：165
- 期：Complete
- 页码：111-119
- 全文大小：1215 K
文摘
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Animal-to-human translation in addiction research has lacked coordination.
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We developed homologous choice procedures in monkeys and humans.
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In humans, choice behavior was a systematic function of cocaine dose and money value.
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Choice behavior in humans and monkeys was functionally equivalent.
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This platform will be useful for screening cocaine use disorder medications.