Computational fluid dynamics modeling of mixing effects for crystallization in coaxial nozzles
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- 作者：Carl Pirkle Jr.a ; b ; Lucas C. Foguthb ; Steven J. Brenekc ; Kevin Girardc ; Richard D. Braatzb ; braatz@mit.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Micromixers ; Static mixers ; Coaxial mixers ; Crystallization ; Computational fluid dynamics ; Population balance models
- 刊名：Chemical Engineering & Processing
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：97
- 期：Complete
- 页码：213-232
- 全文大小：3649 K
文摘
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Cooling/antisolvent crystallization in coaxial mixers is modelled.
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Macro-mixing is modelled using computational fluid dynamics (CFD).
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The population balance equation is discretized and coupled to the CFD code.
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Micromixing within each CFD cell is simulated using a 3-environment model.
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The proposed computational algorithm is applied to crystallization of lovastatin.