Arvestolides A-C, new rare sesquiterpenes from the aerial parts of Artemisia vestita

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• 作者：Shuaihua Tian ; Xingyun Chai ; Ke Zan ; Kewu Zeng ; Xiaoyu Guo ; Yong Jiang ; Pengfei Tu
• 关键词：Artemisia vestita ; Sesquiterpene ; Arvestolide ; X-ray diffraction
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：11 September, 2013
• 年：2013
• 卷：54
• 期：37
• 页码：5035-5038
• 全文大小：660 K

文摘

Three new sesquiterpenes, namely arvestolides A-C (1-3), were isolated from the aerial parts of Artemisia vestita. Their planar structures were determined by extensive analysis of spectroscopic data including MS, 1D, and 2D NMR, and their absolute configurations were resolved by single-crystal X-ray diffraction. Compound 1 is a sesquiterpene with a rare 6/8/3 skeleton, while compounds 2 and 3 possess a rare 5/8/3 sesquiterpene skeleton. Compound 2 exhibited a moderate inhibition effect on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells with an IC₅₀ value of 38.59 ¦ÌM.