Design, synthesis and biological evaluation of novel hydroxamic acids bearing artemisinin skeleton
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- 作者：Vu Thi Haa ; Vu Tuan Kiena ; Le Huy Binha ; Vu Dinh Tiena ; Nguyen Thi Thuy Mya ; Nguyen Hai Namb ; Michael Baltasc ; Hyunggu Hahnd ; Byung Woo Hand ; Do Thi Thaoe ; Tran Khac Vua ; vu.trankhac@hust.edu.vn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Artemisinin ; Histone deacetylase (HDAC) inhibitors ; Hydroxamic acids ; Endoperoxide ; Cytotoxicity
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：66
- 期：Complete
- 页码：63-71
- 全文大小：963 K
文摘
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A new route to hydroxamic acids bearing artemisinin skeleton is described.
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Inhibitory effect relies on the way of artemisinin moiety bound to the HDAC2 protein.
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Six carbon bridge is favorable for cytotoxic activity.