Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity

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• 作者：Pham Hai Yen^a ; Vu Thi Quynh Chi^a ; Phan Van Kiem^a ; ^{phankiem@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Bui Huu Tai^a ; Tran Hong Quang^a ; Nguyen Xuan Nhiem^a ; Hoang Le Tuan Anh^a ; Ninh Khac Ban^a ; Bui Van Thanh^c ; Chau Van Minh^a ; SeonJu Park^a ; Seung Hyun Kim^b ; ^{kimsh11@yonsei.ac.kr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Tacca vietnamensis ; Taccaceae ; Steroidal saponin ; Anti-inflammation
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：1 August 2016
• 年：2016
• 卷：26
• 期：15
• 页码：3780-3784
• 全文大小：722 K

文摘

Using various chromatographic methods, five new steroidal saponins named taccavietnamosides A–E (1–5) and three known, (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→3)]-β-d-glucopyranoside (6), (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→3)]-β-d-glucopyranoside (7), and chantrieroside A (8) were isolated from the rhizomes of Tacca vietnamensis Thin et Hoat. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated RAW 264.7 macrophages and BV2 cells. As the results, compounds 3–5 showed moderate inhibition on NO production in LPS-stimulated BV2 cells and RAW 264.7 macrophages with the IC₅₀ values ranging from 37.0 to 60.7 μM.