New naphthalene derivatives and isoquinoline alkaloids from Ancistrocladus cochinchinensis with their anti-proliferative activity on human cancer cells

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• 作者：Le Quynh Lien ; Tran My Linh ; Vu Huong Giang ; Nguyen Chi Mai ; Nguyen Xuan Nhiem ; Bui Huu Tai ; Nguyen Thi Cuc ; Hoang Le Tuan Anh ; Ninh Khac Ban ; Chau Van Minh ; Phan Van Kiem ; ^{phankiem@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Ancistrocladus cochinchinensis ; Isoquinoline alkaloid ; Naphthalene derivative ; Anti-proliferation
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 August 2016
• 年：2016
• 卷：26
• 期：16
• 页码：3913-3917
• 全文大小：415 K

文摘

Five new compounds, named ancistronaphtosides A and B (1 and 2), anciscochine (3), anciscochine 6-O-β-d-glucopyranoside (4), and 4′-methoxy-5-epi-ancistecrorine A₁ (5), together with tortoside A (6) and 4-hydroxy-2-methoxyphenyl-6-O-syringoyl-β-d-glucopyranoside (7) were isolated from the methanolic extract of Ancistrocladus cochinchinensis. Their chemical structures were established using HR-ESI-MS, NMR spectroscopic, and chiroptical methods. Compound 5 significantly exhibited anti-proliferation against HL-60, LU-1, and SK-MEL-2 cells with IC₅₀ values of 5.0 ± 1.2, 6.5 ± 1.6, and 6.8 ± 2.0 μg/mL, respectively.